Aku harus optimis, Allah Maha Kuasa, yang dapat mengubah nasib seseorang dengan usaha atau keajaiban…

—–Trah7—-

Zara Hartshorn is just 13-years-old, but she suffers from a rare genetic condition called Lipodystrophy so she looks old beyond her years. She has been called ‘grandma’, ‘monkey’ and ‘baggy face’ and the bullying got so bad that her mom had to pull her out of school.
Even though she is only 13, Lidopystrophy makes her look like she could be someone’s grandmother as her face is that of a grown woman, and wrinkled.
“It feels like people are looking down their noses at me and staring,” she said at her home in northern England. “You know when you get that feeling you’re being watched? I feel that everywhere I go.”
Source: abcnews.go.com

Zara’s mother Tracey was also born with Lipodystrophy and she knows what Zara is going through. She could tell Zara suffered from the disease when she was just a newborn:
“I was grieving for a child that’s got to go through the same things in life that I’ve had to go through,” she said. “I was angry at myself for actually having Zara.”
Source: abcnews.go.com

When someone suffers from Lipodystrophy the body cannot produce fat cells under the skin so the aging process is so much faster. There is no cure and due to the rapid aging it can bring about diabetes, stroke and liver problems.
Zara is the strongest sufferer in her family. Three out of Tracey’s seven children suffers from Lipodsytrophy.
When asked what she feels when she sees her own face in the mirror, Zara said, “I don’t like it. Sometimes I’ll sit in my room and start pulling my skin back, stuff like that. Most teenagers worry about getting spots…. I’m worried about surgery and stuff like that and when’s bullying going to stop.”
Source: abcnews.go.com

Zara said that the thing she wants most is a face-lift, but her mother says surgery doesn’t help much.
Tracey says that she fears Zara will end up like her, with a string of abusive relationships, no career and low self-esteem due to her condition.
“I don’t want [Zara] ending up like me,” she said. “Surrounding herself with seven, eight or however many kids just to feel loved…. And she doesn’t need to go from one man to another looking for something she’ll never find.”
Source: abcnews.go.com

Zara wants to be a beauty therapist when she is older; for now she is working on stepping outside her front door without people making fun of her.

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Mangkubumi Trah7

Diabetics
may experience localised lipodystrophy at repeated injection sites.
Other injections
Lipodystrophy has been reported to follow injections with penicillin, iron, growth hormone, vaccines and acupuncture.
Panniculitis

Panniculitis
is the term used for inflammation of subcutaneous fat. It is sometimes followed by permanent loss of fat. Fat atrophy is particularly likely in
lupus panniculitis
(lupus profundus) and some forms of
morphoea
.
Progressive hemifacial atrophy (Parry-Romberg syndrome)
Progressive hemifacial atrophy is characterised by thinning of skin, fatty tissue and underlying bony structures of one side of the face. Onset is usually during childhood. The cause is unknown.
Localised lipodystrophy

Atrophy due to steroid injection

Subcutaneous morphoea

Lupus panniculitis
Generalised acquired lipodystrophies are rare. They include:
Generalised lipodystrophy (Lawrence syndrome)
Generalised lipodystrophy is a rare disorder with loss of fat during childhood and adolescence. Females are affected more often than males. It may occur following infections such as chicken pox, measles and whooping cough. Often it is associated with elevation of blood cholesterol and diabetes.
Partial lipodystrophy (Barraquer-Simons syndrome)
Partial lipodystrophy usually occurs around 10 years of age after a viral illness. Fat is lost from the face and trunk, but the legs and hips are spared. Fat may accumulate in the legs and hips in women. Females are affected three times more often than males. One third of patients develop kidney disease (membranoproliferative glomerulonephritis with hypocomplementaemia).
Partial lipodystrophy is also associated with auto-immune disorders including systemic lupus erythematosus, hypothyroidism and
rheumatoid
arthritis
.
Lipodystrophy associated with human immunodeficiency virus
This form of lipodystrophy is associated with longterm treatment with antiretroviral drugs (protease inhibitors and nucleoside reverse transcriptase inhibitors) and
human immunodeficiency virus
(HIV) may contribute. The exact mechanism is not known. Fat is lost from the face, arms, legs and buttocks. Fat may accumulate on the neck and upper back.
In many cases of acquired lipodystrophy, the cause is unknown.
Congenital lipodystrophy
Congenital lipodystrophy can be generalised or partial. Recent advances have identified some genetic abnormalities.
Generalised congenital lipodystrophy (Berardinelli-Seip syndrome)
Generalised congenital lipodystrophy is a rare disorder with gene mutations of seipin or AGPAT2 gene. It is characterised by high levels of insulin (insulin resistance) and high levels of blood fats. It results in gigantism (acromegaly), enlarged liver and kidneys, pancreatitis,
acanthosis nigricans
and increased body hair
(hypertrichosis)
as well as generalised loss of body fat.
Partial congenital lipodystrophy
Familial partial lilpodystrophy is associated with
metabolic syndrome
(syndrome X) including hypertension, insulin resistance, diabetes and severe hypertriglyceridemia resulting in pancreatitis and premature coronary artery disease. Sometimes partial loss of fat results in other areas of fat enlarging to compensate.
Familial partial lipodystrophy spares the face and is inherited as an autosomal dominant disorder (half of the children of an affected individual will also be affected). There are two subtypes:
Type 1 (Kobberling syndrome), with fat loss from the extremities, and central obesity. It has only been reported in females.
Type 2 (Dunnigan syndrome), with fat loss from the extremities, abdomen, and thorax. This is due to a mutation of lamin A/C gene or PPAR gamma gene (part of the nuclear membrane within the cell). Mutations in this gene can result in a variety of other rare diseases including muscular dystrophy, cardiomyopathy, neuropathy and (
progeria
and are collectively termed laminopathies.
Other types of congenital partial lipodystrophy have also been described including SHORT syndrome and mandibulo-acral dysplasia.
Treatment
The treatment depends on the cause of the lipodystrophy. It can involve:
Cosmetic procedures such as fat transfer (moving fat from one part of the body to another using
flaps
and
grafts
),
injectable filers and implants

Managing diabetes and high cholesterol
Altering HIV treatments
Medication such as anabolic steroids.